Graded doses of cDCs were added as indicated in Results section.
The overall quality of the evidence was graded using Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.
A 5% occurrence of grade 3 neurotoxicity, seen here, is consistent with other studies using similar doses of paclitaxel (Mavroudis et al, 2002).
For the neurotoxicity, an oxaliplatin-specific scale was used: grade 1, paresthesias or dysesthesias of short duration, but resolving before the next dosing; grade 2, paresthesias persisting between doses (2 weeks); and grade 3, paresthesias interfering with function.
In the case of grade-3 to grade-4 adverse events, treatment was continued after resolution of the event using doses of L-OHP, CPT-11 and capecitabine reduced by 25%, except in the case of grade 3/4 diarrhoea, when only CPT-11 and capecitabine doses were reduced by 25%.
Traditional dose-limiting toxicity (DLT) definition, which uses grade (G) 3 4 toxicity data from cycle 1 (C1) only, may not be appropriate for molecularly targeted agents (MTAs) of prolonged administration, for which late or lower grade toxicities also deserve attention.
All that James really delivered Friday, aside from a pharmaceutical-grade dose of euphoria, was a 1-1 tie.
For patients who developed grade 3 or 4 adverse events, the dose of lenalidomide was withheld until the event resolved, and treatment was restarted using a dose of 15 mg/day, with further reductions in 5 mg decrements as needed.
Sounds as if Kendrick could use a dose of Brad Gilbert.
