Because line fitting using global analysis requires extremely high quality data, this method of analysis proved impractical [29].
The global analysis method is used here to obtain numerical properties at each node of the full domain.
This motivated us to evaluate the lifetime data using a 'quasi-global' analysis method, where profiles were fit to a 4-component multi-exponential fit, with 2 lifetimes held constrained to those measured in NADH solution, our designated reference emitter [ 17, 52].
Model calibration using global optimization methods.
However, using global methods should not lead modellers to forego local methods, which provide additional information, as, for example, time course analysis of local sensitivity coefficients.
By using global methods, the effects of nonidentifiable kinetic parameters on sensitivity analysis results are greatly mitigated.
Initial analysis of all known forkhead genes simultaneously using global or local alignment methods, and parsimony, likelihood or Bayesian phylogenetic methods, produced trees with inconsistent subfamily placement due to low sequence homology outside of the forkhead domain among different subfamilies.
Often the first stages of biomarker screening involves selecting the genes showing the largest and/or most significant fold changes in expression between different experimental groups, and studying the differences in global expression profiles using multifactorial analysis methods such as Principal Component Analysis (PCA) and ANOVA.
Using this analysis method, the global ventilation performance would have been considered inefficient according to the tolerance range defined by the authors (510 595 ml), while they actually recorded optimal VT on 22% of occasions.
Recon 1, a global human metabolic network reconstruction [ 17], with elementally charge and mass balanced equations can be used for analysis of transcriptomic, proteomic, and metabolomic data [ 19] using constraint-based analysis methods [ 20, 21].
