The potential for using genomic technologies in association mapping and breeding depends largely on the genome wide patterns of diversity and linkage disequilibrium in current breeding populations.
Using a question and answer format we describe important aspects of using genomic technologies in cancer research.
For example, evidence that cfDNA is tumour derived using genomic technologies may provide more information about genomic alterations of clinical significance (Shaw et al, 2011).
In Part 3, Paul Schulte covers workplace issues and occupational health and the potential uses and challenges arising from genetic testing and surveillance using genomic technologies.
Last decade of experimental work using genomic technologies has provided many data on gene expression profiling of different biological and pathological states [ 1].
Profiling of blood transcriptomes by using genomic technologies, such as microarray, provides a snapshot of transcriptional activities in peripheral whole blood that can be used to characterize molecular signatures present in the sample.
Capturing the host response by using genomic technologies such as transcriptional profiling provides a new paradigm for classifying and diagnosing infectious disease and for potentially distinguishing infection from other causes of serious respiratory illness.
Battling neglected infectious diseases is an important priority of the Bill & Melinda Gates Foundation (http://www.gatesfoundation.org), which has committed more than US$1.02 billion for research on methods of treatment and prevention, using genomic technologies in some cases.
Indeed, one might argue that by using genomic technologies in order to find as many fetal abnormalities as possible, is very much in line with the autonomy paradigm, as this would maximally expand the range of options for reproductive choice.
She discussed her experiences using genomic technologies to identify molecular targets for individual patients, including a cryptic fusion of PML-RARA oncoprotein in a patient with acute promyelocytic leukemia, and overexpression of FLT3 in an acute lymphoblastic leukemia patient.
