The economists' solution to such trade-offs (one intervention more effective, but more costly than another) is to use generic measures of health-related quality of life capable of generating such indicators as the quality adjusted life year (QALY) [ 35, 36].
One of the most commonly used generic measures of health-related quality of life (HRQoL) is the Short Form 36-Item Survey version 1.0, developed in the RAND Medical Outcomes Study during the 1980s [4].
Of the RCTs reviewed, none used generic measures of participation or other health-related quality of life or health status measures.
Alternatively, commonly used generic measures of HRQoL including the SF-6D, Health Utilities Index (HUI) and the EQ-5D have also been used in CVD studies [ 9- 11].
The purpose of this analysis was to use generic measures of HRQL to describe HRQL deficits associated with varying degrees of severity of type 2 diabetes.
However, the bulk of research investigating the prevalence of DEB in type 1 diabetes uses generic measures of DEB or diabetes-adapted generic measures with an additional question about insulin misuse.
The SF-6D, which is derived from the 36-item Short Form Health Survey (SF-36), is one of the most widely used generic measures of HRQoL in clinical trials.
However, the recent development of the SF-6D, which is derived from the Short Form 36 (SF-36) health survey [ 18], one of the most widely used generic measures of health-related quality of life in health services research, has the potential to considerably increase the derivation of QALY estimates using existing and future data sets [ 17].
These questions were designed for the study in consultation with a psychologist on the project and took the form of self-statements (e.g., "I am a religious person" or "My illness has caused me to worry about life and death issues").. Together, the SF-36 version 1 and version 2 are the most widely used generic measures of self-perceived health status and HRQL in health care [ 57- 59].
