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Moreover, by using different cell systems, we demonstrated that the impaired integration of RA signal at a mutant RARα induces a repression wave that is propagated, in a domino fashion, from RARβ2 to targets downstream of RARβ2.
In vitro studies using different cell systems showed varying degrees of proinflammatory-and oxidative-stress related cellular respoxidative-stress relatedlaboratory-generated or filter-cellulard ambient UFPs (Bresponsesl. 2000, 2001; Li et after003).
This result is the opposite of that recently reported by two other groups of workers using different cell systems, but in agreement with the results of a third group of workers.
These results showing the induction of neoplastic transformation by long-term exposure of nontumorigenic cells to low doses of arsenite are consistent with those of several other studies using different cell systems (Achanzar et al. 2002; Huang et al. 1999; Mure et al. 2003; Zhao et al. 1997).
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However, the discovery of stem cell plasticity, and continuous breakthroughs in verification of the causal relationship between molecules and aging-related diseases, for example, using different cell culture systems and animal models, have provided opportunity for collaborative innovation in the research on aging and aging-related diseases.
Identification of such proteins from COS7 cells was not pursued further and left for the future investigation using different cell culture system.
The immatureness of the chick embryo immune system allows using different cell types and cells from different tissues and species.
It is thus possible that prion strains use different cell entry pathways to establish persistent infections in different cell populations.
An advantage of using these different cell systems is that some are more sensitive than others and thus may identify additional compounds as agonists compared with using a single cell type (Table 2).
Given the use of different cell systems, it is difficult to compare the differentially expressed genes in AML1-MTG16-positive 32D cells with the differentially expressed genes reported for AML1-MTG8.
Cancer biologist Piyush Gupta of the Whitehead Institute in Cambridge, Massachusetts, who has used a different cell system to find drugs that target cancer stem cells, says he would not necessarily expect the pluripotent stem cell system to mimic cancer.
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