Exact(3)
First, based on computational models, a systems drug discovery scheme is introduced using database mining and high-throughput data, including the validation of drug targets via cross-referencing of experimental data, pharmacogenomics, polymorphism haplotyping, and the understanding of drug metabolism and toxicity.
In addition, the expression pattern of gene members was studied using database mining and in situ hybridization tools.
Using database mining, molecular cloning, heterologous expression and enzyme assays, we isolated five putative UDP-glycosyltransferases from flax seeds and demonstrated that UGT74S1 glucosylated SECO, forming sequentially SECO monoglucoside (SMG) and then SDG.
Similar(57)
Mint.com (now owned by Intuit) uses database mining to synthesize spending trends for regions and "people like me," which allows people to compare their spending habits with others'.
Using both database mining and experimental methods, we isolated the full-length primary transcripts of the mouse miR-433 and miR-127 and demonstrated that they overlapped in a 5'-3' unidirectional way.
To understand the regulatory function of SHP with regard to miR-206 gene expression, we determined the putative transcriptional initiation site of miR-206 and also its full length primary transcript using a database mining approach and RACE.
Therefore, to better understand the functional role of the CatSper channel complex, we set out to determine the evolutionary origins and patterns of CatSpers and CatSperβ using extensive database mining and rigorous phylogenetic analyses, and to analyze the evolutionary rates and functional divergence of CatSpers and CatSperβ.
More than 30 defensins in human and mouse [11] and 14 β defensins in birds [12], [13], [14] were identified, but only 3, 2 and 2 β-defensin genes were respectively found in zebrafish, Fugu and Tetraodon by using a database mining approach.
Using genome database mining and other informatics approaches, we identified and characterized the repertoire of 54 intact "V2R-like" olfactory C family GPCRs in the zebrafish.
Instead of using databases as a storage medium, databases now are also used as a source for data-mining applications.
Based on that, we re-analyzed the DNA microarray data set by using in silico database mining procedures identifying novel candidates with differential expression in the course of bladder cancer progression (data not shown).
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