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Virtual screening is a process based on using computational methods to identify chemical compounds that have high chance to interact with a specific biological target [6].
When an animal's gene more closely matched a gene from a nonanimal than any other animals, the researchers took a closer look, using computational methods to determine whether the initial database search had missed something.
Using computational methods to fill in sparse data will not only rescue poorly resolved data but may also be applied to identify biomarkers, project clonal evolution, or rank potential drug responses.
Thus, using computational methods to screen for putative sites prior to experimental verification can narrow down the efforts on experimental work.
With the rapid growth of genome sequences and gene expression profiles, there is increasing concern about using computational methods to determine the linkages between protein sequences and their biological functions [1], [2], [3], [4].
Typically after an organism's genome sequence is determined, structural annotation is performed using computational methods to make gene model predictions.
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Our work is the first demonstration of using computational method to precisely quantify the degree of stress in a cell in terms of mitochondrial shape change, by using an automated tool for mitochondrial shape classification.
As well, we can use computational methods to develop predictive models.
Often this can consist of conscious allusions — Bamman and his colleagues used computational methods to zero in on the places in "Paradise Lost" where John Milton is alluding to the Latin of Virgil's "Aeneid".
In this study we used computational methods to design novel C5a1 receptor ligands.
In this work, we used computational methods to examine the gate structure of ZIF-8 tuned by substitution terminal groups.
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