On the other hand, if a large proportion of nodes in a network have to be modified in order to achieve recovery, then a different pharmaceutical strategy using compounds that can simultaneously affect multiple molecular targets should be followed.
Although also expressed in the brain, CLDN5 may represent a target for antiangiogenic therapy, especially if using compounds that cannot cross the blood-brain barrier.
More convincing validation would be to use compounds that have many known targets, such as vitamin E with 14 known targets and 4H-tamoxifen with ten known targets which were used in the test for TarFisDock (Li et al. 2006).
These advances show the promise of using novel compounds that target the histone methylation/demethylation pathway as an innovative approach to breast cancer treatment, and are anticipated to lead to the development of a new generation of therapeutically effective epigenetically-active drugs with considerable clinical potential.
The bioluminescence resonance energy transfer technique can be used to screen for compounds that target the extracellular part of the LR, and we propose that the novel reverse mammalian protein protein interaction trap technique can be used to screen compounds that affect intracellular aspects of LR signalling.
Using phenotypic drug screens to identify compounds that target multiple age-associated pathologies, the laboratory of David Schubert has identified plant-based polyphenolics, including curcumin, as lead compounds for drug development.
Bioactive compounds that target human proteins generally fall within the established parameter range for Lipinski 'drug-like' compounds and were therefore used as comparator benchmarks.
An alternative then is development of novel antimicrobial compounds that target bacterial endosymbionts of arthropod pests and vectors but whose application is limited to that use.
Several new drug compounds that target the complement system are in development (Table 3), but are not currently approved for clinical use (Ambati et al., 2013).
In the beginning of glycolysis we used 3PO, a compound that targets PFK2 thus inhibiting the phosphofructokinase step (Schoors et al., 2014).
