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Multivariate analyses examined HIV and STIs as outcomes, with some studies using composite measures of HIV and STIs.
Response assessment should be done using composite measures of disease activity, such as DAS, DAS28, SDAI and CDAI.
Campbell and Parker 22 similarly found an absence of significant multicollinearity when using composite measures of socioeconomic status together with education and occupation.
While several different measures have been employed in various strategy trials, 21 expert opinion has recently suggested using composite measures of disease activity which include joint counts.
This item reiterates the importance of using composite measures of disease activity, but indicates that other aspects such as functional impairment and joint damage, which are governed by the degree of disease activity, also have to be considered.
The Committee was convinced that using composite measures of disease activity constitutes the best way to judge disease activity and response to therapy, although this is an expert opinion (category IV).
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Insulin use and A1C are commonly used composite measures of diabetes control.
Studies that used composite measures of diabetes self-care that tapped into more than one aspect of self-care also found stronger effects.
To more completely describe inflammation, we propose that research into the inflammatory basis of morbidity and mortality should also use composite measures of inflammatory biomarkers.
Two previous studies used composite measures of asthma control including (1) no recorded hospital attendance for asthma (including admission or ED visit, out of hours, or outpatient department attendance); (2) no prescription for oral corticosteroid and (3) no consultation, hospital admission or ED attendance for lower respiratory tract infection requiring antibiotics.
These measures included sex, father's social class (manual v non-manual), cognitive ability at age 8 (a previously used composite measure of reading, vocabulary, and arithmetic tests), 24 and symptoms of depression and anxiety at age 13 and 15 (a previously used composite measure of teacher reported symptoms).
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