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The question arises whether in vitro millimolar concentration relate to the ones achievable in vivo by using clinical doses of the drug.
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However, based on a study concluding that the effects of antithrombin on prognosis and coagulation and fibrinolysis parameters are independent of the doses administered (30 or 60 IU/kg) in patients with sepsis-associated DIC, we chose the widely used clinical dose of 30 IU/kg [ 26].
The cell dose used in this study is 50-fold the currently used clinical dose.
Clinical dose assessment (using clinical exposure data) provide valuable information on the clinical practice and takes into account the influence of breast thickness and composition on dose [6].
For relevance to clinical radiotherapy, we treated cells and tumours with standard radiation doses of 2 10 Gy, using clinical linear accelerators.
As there is a relation between the extent of annoyance and stress, future research should define this on a dose response basis using clinical as well as subjective exposure outcomes.
This is equivalent to four times the clinical dose of AS-AQ (4 × clinical dose of AS-AQ).
This is equivalent to double the clinical dose of AS-AQ (2 × clinical dose of AS-AQ).
Thirdly, we used a supra-clinical dose of exendin-4 to identify specific remodelling actions and effects of lower therapeutic levels were not assessed.
Here, with etoricoxib, discontinuations could be examined in detail because large numbers of patients participated in good quality and well recorded clinical trials, using different doses of etoricoxib and comparators in different clinical conditions.
However, causation has not been proved, and well-designed randomized, controlled clinical trials using sufficient doses of vitamin D to alleviate manifestations of mental and cognitive illness still need to be performed.
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