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Our approach to select promising candidates for mapping brain eQTL using blood as a surrogate tissue included very restrictive criteria for probe filtering.
The high-quality tissue and RNA resource that we have established will be extremely valuable for mapping brain expression traits using blood as a surrogate tissue.
Those studies appear to be in progress; meanwhile, the utility of using blood as a neural probe continues to be frequently raised as an objection by critics to these studies.
Here we report a comprehensive evaluation of the degree of eQTL overlap between blood and brain and aim to determine the validity of using blood as a surrogate for brain tissue.
A key motivation of this work was to provide information on the utility of using blood as a surrogate for brain tissue when trying to understand the role of gene expression in neurological and psychiatric conditions.
The rationale for using blood as a clinical sample is that breast cancer triggers a response in circulating blood cells, leading to a traceable change in the whole blood gene expression signature.
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But perhaps Palin just used "blood" as a sort of exclamation point.
To minimize the chance of amplifying numts, we did not use blood as a source for DNA-extractions in our recently collected material [17], [21] (in the older specimens it was not possible anyway).
Therefore, we no longer use blood as a BAPGM supplement.
We used blood as a proxy for liver because sampling liver tissues is a difficult and invasive procedure.
In recent years researchers have increasingly used blood as a matrix for characterizing exposure to nonpersistent chemicals.
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