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Using bioinformatic analyses and experimental evidence, we characterize the unusual multichromosomal architecture of mtDNA in Glomeormycota.
Many putative mutacin-encoding genes have been previously predicted using bioinformatic analyses and some of them were functionnally verified using mutational analyses for S. mutans UA159 [ 23].
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The clinical significance of this signature and the underlying biology were investigated using bioinformatic analyses in clinical breast cancer datasets, and knockdown validation approaches in tumor xenografts.
Using bioinformatic analyses, 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes were predicted.
Six of these were either known Type I substrates (PlyB and RapA2) [ 62] or were predicted above (RL2961, pRL100309, pRL90140 and RL2412) to be secreted using bioinformatic analyses.
Using bioinformatic analyses, we found that the STAR elements were located in different genomic loci within each staphylococcal species.
It was recently identified by Zhang et al. [ 1] using bioinformatic analyses of the preproghrelin genomic sequence in different species.
Using bioinformatic analyses, we confirmed that helveticoside is a biologically active component of EEDS that induces reciprocal regulation of metabolism and signaling processes.
To understand the mechanisms by which miR-133a suppresses tumor cell invasion and metastasis in breast cancer, we identified FSCN1 as one of potentially miR-133a targeting genes using bioinformatic analyses.
In the case of A. thaliana, the suitability of the clones for CP was double-tested using bioinformatic analyses of BAC sequences as well as dot-blot hybridisation (Lysak et al. 2003).
Whilst it was possible to place most of the trypanosomatid ePKs into the seven established groups using bioinformatic analyses, it has not been possible to ascribe function based solely on sequence similarity.
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