Taking into account that we used atria and ventricles from a 15-week-old human heart, consisting of cardiomyocytes, endothelial cells, smooth muscle cells, fibroblasts and other cardiac cells, a 30% overlap can be considered as a strong correlation.
Participants had an electrocardiogram (ECG) using the Atria 6100 automated system [ 23].
Compounds 2a, 2b, 2c, 4c and 4f proved to exert cardiotonic activity comparable to that of milrinone using spontaneously beating atria model from reserpine-treated guinea pigs.
D. J. Gauthier, G. M. Hall, R. A. Oliver, E. G. Dixon-Tulloch, P. D. Wolf, and S. Bahar, 'Progress toward controlling in vivo fibrillating sheep atria using a nonlinear-dynamics-based closed-loop feedback method,' an Invited Article in the Theme Issue on Mapping and Control of Complex Cardiac Arrhythmias, Chaos 12, 952 (2002).
This finding also fit the idea that cooling may induce a transition from β- to α-adrenoceptor properties, as suggested in a study using isolated rat atria [ 13].
In the next step the potential cardiotonic activity of the best PDE3A inhibitors (4b, IC50 = 0.43 ± 0.04 μM) was evaluated by using the spontaneously beating atria model.
Similar studies using the entire 3D atria models can be very expensive computationally.
Daylight performance is measured based on the proportions of an atrium that are defined by Well Index (WI), used to characterize atria.
We apply this method to signals recorded during arrhythmias in human atria and ventricles using a multipolar contact catheter and show that the flow fields correlate with corresponding activation maps.
After stabilization of Langendorff preparation, acute stretch of the atria was performed using the method originally described by Ravelli and Allessie.
