Insight into their relationship with hepatic encephalopathy (HE) can be obtained using animal models of HE.
Using animal models of early-life hypoxia ischemia, losses of particular interneuron populations were reported.
Early studies using animal models of colon cancer indicated that NSAIDs were chemopreventive (Kudo et al., 1980; Pollard and Luckert, 1981).
Reynolds, S., Lane, S. J. & Richards, L. Using animal models of enriched environments to inform research on sensory integration intervention for the rehabilitation of neurodevelopmental disorders.
As discussed below, some of these actions have been examined using animal models of drug discrimination/reinforcement and single neuron electrophysiological approaches.
Thus, the overall theme of our research program is identifying the mechanisms by which bariatric surgery causes these health benefits using animal models of bariatric surgery.
For example, discoveries using animal models of SCN1A or ARX mutations implicate a predominant role for interneurons due to disturbed GABAergic function.
Since allogenic matings are more similar to those that occur in humans, future studies using animal models of microchimerism should consider incorporating this type of experimental design.
In a separate study published by the GSK team in the same issue of Science Translation Medicine, the beneficial effects of TRPV4 inhibition in reducing pulmonary edema were independently validated using animal models of pulmonary edema caused by heart failure.
Using animal models of compulsive behaviors give much more possibilities to study the deficient functions and their underlying neural basis that could lead to pathological repetitive behaviors.
Finally, genetic research using animal models of diabetes will provide new directions for research in humans to delineate the genetic contribution to the development of diabetes.
