The designed segmentation method can be extended to images for which it is required to segment a region of interest using an unsupervised approach.
Using an unsupervised approach to classify data from TCGA, Verhaak et al. described 4 GBM transcriptomal subtypes, termed Proneural, Neural, Mesenchymal and Classical [36].
In 2/11 studies using an unsupervised approach, participants were willing to pay between (>US$20 to ≥US$50) [ 45, 46].
Using an unsupervised approach, we have identified five clinically relevant subtypes of breast tumors [ 4, 8], which have been further validated in independent data sets [ 3, 9- 14].
In a study of 157 archival FFPET samples aged 2 8 years, correct classification of tumour type and subtype using an unsupervised approach suggests that biological data are more powerful than 'block effects' (Penland et al, 2007).
Privacy was more frequently reported as a benefit of HIVST in studies using an unsupervised approach (n = 5/6) [ 15, 30, 38, 45, 46] compared to those using a supervised approach (n = 2/6) [ 35, 37].
In [19], the authors used an unsupervised approach to adaptively identify the confidence of features in different circumstances.
Compared to previous studies [8, 12 17], we do not start with the location and the time of an already known event, but we use an unsupervised approach that spatio-temporally identifies unusual calling behavior.
Recent microarray analyses used an unsupervised approach to identify different molecular subtypes in medulloblastoma [30].
We next used an unsupervised approach to identify significant associations between genome-wide TF-binding data and gene expression.
This work used an unsupervised approach to predict the links based on several network toplogy features in co-authorship networks.
