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Using an unbiased method to probe chromatin accessibility genome-wide, we uncover unique features of chromatin structure that are not observed using more widely-utilized methods.
To confirm this result using an unbiased method to recover rho0 cells, we searched for spontaneous rho0 clones (rho0 sp). in untreated wild-type populations (see Materials and Methods).
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To classify patterns of activity amongst these ΔF/F traces, we used an unbiased method and clustered the stimulus and swimming evoked groups separately24.
We first used an unbiased method, MSRF, to identify both hypo- and hyper-methylated sequences in the high PAH group compared to the low PAH group.
Only eight study cohorts were prospectively investigated for the primary reason of identifying a foot disease disorder or risk factor; 32 37 40 42 47 83 106 107 however, only one used an unbiased method of measurement.
To quantify power spectra of signals and compare differences in spectral composition, we used an unbiased method by calculating the median, first spectral moment and second spectral moment of the acquired power spectra.
In order to determine the rate of ripples and of fast ripples that were not harmonics due to a non-sinusoidal ripple waveform, we used an unbiased method to identify HFA events of six or more cycles based on thresholding HFA cycles at five times the overall signal standard deviation and characterized them as ripples and fast ripples by their median interspike intervals (Fig. 5A and B).
For each group, the time course of tissue loss was described and the gliosis volume over the first postoperative month was evaluated using an unbiased stereological method.
A minimum of 15 electron micrographs of midgut sections of each sample were taken at 10,000-15,000x, using an unbiased sampling method.
Interestingly, using an unbiased clustering method of all mapped Tip60 reads against ENSEMBL TSS, and we observed that all transcriptionally active genes (Pol II positive) show Tip60 enrichment.
The total number of tyrosine hydroxylase-positive neurons was estimated using an unbiased stereological quantification method and employing the optical fractionator principle (Stereo Investigator) (Ulusoy et al, 2010).
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