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We have shown that many susceptibility loci in MS are associated with changes in gene expression using an unbiased expression database.
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The purpose of the present study was to build a genomic signature able to predict FDG uptake intensity in a diverse population of metastatic tumors, by using an unbiased gene expression profiling not limited to a predefined set of genes, but rather using whole human genome gene expression microarrays.
In this re-analysis study, we explored suicide candidate genes associated with bipolar disorder and schizophrenia using an unbiased genome-wide expression profiling strategy.
First, we coupled PBMC gene expression profiling to IPF clinical traits using an unbiased "Weighted Gene Co-expression Network Analysis (WGCNA)" approach which is useful for describing the pairwise correlated expression among gene transcripts with co-regulation implications [ 19– 21] and to restrict the search space of genes to those genes in modules associated with pulmonary function.
Using an unbiased genome-wide gene expression profiling approach, we identify DR5 as a novel key mediator of Smac mimetic-induced apoptosis.
Using an unbiased, array‐based, genome‐wide gene expression analysis approach, we identified 274 probes with >2‐fold change and p < 0.01 (when corrected for multiple comparisons).
Using an unbiased discovery approach, the expression of 13 genes (including HDM2) was found to have robust and superior predictive value for response compared to p53 wild-type status alone.
The objective of this study was to identify genes that are differentially expressed in brain tissue of intracranially infected monkeys compared to non-infected ones using an unbiased genomic approach such as expression microarrays with subsequent data validation by RT-qPCR.
In this study we have distinguished gene expression aberrations across mild/moderate dysplasia (CIN I, CIN II) in addition to CIN III and non cancerous (NC) cervical epithelium using an unbiased long serial analysis of gene expression (L-SAGE) method that simultaneously allows for the discovery of tags which map to HPV 16.
First, we tested all SNPs using an unbiased association design.
Using an unbiased transcriptomics approach, we found that cardiac glycosides inhibit general protein synthesis.
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