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Identifying critical proteases involved in Htt proteolysis and toxicity using an unbiased approach has not been reported.
Using an unbiased approach we compared the blood leukocyte transcriptome of sepsis patients who were on statin therapy (N = 157) versus those who were not (N = 337).
To comprehensively classify fibroblast populations in the lung using an unbiased approach, single-cell RNA sequencing was performed with mesenchymal preparations from either uninjured or bleomycin-treated mouse lungs.
Using an unbiased approach to substrate identification, we performed quantitative proteomic analysis of two human epithelial cell lines stably expressing BACE1 and identified 68 putative β-secretase substrates, a number of which we validated in a cell culture system.
To ensure that the NFAT transcription factors were included in our analysis using an unbiased approach, we resubmitted a gene list to InnateDB containing the 2,989 genes, and then visualized protein level interactions between genes using Cytoscape and the software plugin Cerebral.
Using an unbiased approach we have revealed that a hyperglycemic state affects the cytotoxic immune capacity.
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Here we studied the transfer of the three major NSPs, namely proteinase 3, human neutrophil elastase, and cathepsin G, from neutrophils to endothelial cells and used an unbiased approach to identify novel endothelial NSP substrates.
Phage display panning uses an unbiased approach to select short peptides that bind to over-expressed cell surface targets.
To test our hypothesis we chose to use an unbiased approach to look for co-occurrences among all entries in the PSL.
To address the hypothesis that UAG can modulate metabolic pathways relevant to insulin sensitivity, we used an unbiased approach: transcriptome-wide expression profiling of liver, muscle and white adipose tissue (WAT).
We used an unbiased approach, i.e. an unrooted tree.
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