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Right panel shows the docking accuracy using an optimized box size.
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It calculates Delaunay diagram by using an optimized incremental algorithm.
DNA was extracted using an optimized in-house method [ 15].
Hybridization was performed using an optimized low-background protocol [ 30].
We, therefore, used an optimized computation method.
To illustrate the improvement in docking accuracy using the optimized box size, we selected a 315 aa human aldose reductase holoenzyme complexed with nicotinamide-adenine-dinucleotide phosphate, NADP (PDB-ID: 1ads, chain A); this enzyme has been implicated in the development of diabetic and galactosemic complications [48].
Using the optimized box size in Vina improves the performance of virtual screening to 8.131, 3.443, 0.234, 0.703 and 0.234.
Large-scale benchmarking calculations on the DUD-E dataset show that using the optimized box size also improves the ranking accuracy in virtual screening over the default protocol.
Initially, ten variables were considered for screening using Plakett-Burman design (PBD) to identify the variables, which significantly influenced α-L-arabinofuranosidase production, and in the second stage the significant variables screened from PBD were further optimized using a Box-Behnken design (BBD).
The extraction of the hydrophilic components was optimized by using a Box-Behnken design that considered the influence of temperature, solid/liquid ratio and methanol concentration on the maximization of the following responses: extraction yield, total phenols (Folin-Ciocalteu) and antioxidant capacity (DPPH).
Avoid using a standard electrical box.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com