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These observations were partially confirmed by Du et al. using an immunohistochemical study; they added that Mena intensity does not depend on the histological type of HER-2-positive breast carcinomas and can also be observed in about 7% of normal breast tissue [ 23], although Di Modugno et al. denied detection of hMena isoforms in normal breast tissue [ 5, 8].
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Here we used an immunohistochemical study of human epidermal SCC to determine whether Bag-1 and/or Hsp70 expression was altered during squamous cell carcinogenesis of the skin, and whether Bag-1 expression was related to Hsp70 or p53 staining.
The monoclonal antibody Y13 259 to the ras oncogene protein product p21 was used in an immunohistochemical study of ras expression in human colorectal neoplasms.
Our aim was to determine human tumour vascular maturity using an immunohistochemical angiogenic profile, and to study any relationship with CA4P response assessed by change in DCE-MRI kinetic variables.
An immunohistochemical study using a monoclonal antibody specific for AGE proteins showed extracellular AGE immunoreactivity in amyloid plaques in different cortical areas, in particular, primitive plaques, coronas of classic plaques and some glial cells in AD cortex were positive for AGEs [ 115].
In an immunohistochemical study using non-tandem repeat antibodies, there was de novo expression of MUC5AC in 23/36 carcinomas.
To examine the localization of the identified cytoskeletal proteins, we conducted an immunohistochemical study using confocal scanning microscopy and immuno-electron microscopy.
However, an immunohistochemical study using a polyclonal antibody showed that some kind of C-terminal truncated CD20 was present in cytoplasm, so it was possible that the epitope of L26 was lost by gene mutations.
In the present paper, we performed an immunohistochemical study using tissue microarrays (TMA) containing a broad panel of human normal tissues (Tissue Array Network, Rockville, MD, USA), in search for possible human cell-type-specific expression of HSPA2 and HSPA1 proteins.
In addition to in situ hybridization, an immunohistochemical study was performed using the avidin-biotin complex (ABC) method as described before [ 15].
This study used an immunohistochemical method to detect the expression of γ-synuclein in paraffin-embedded tissues from Chinese's patients with endometrioid endometrial carcinomas.
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