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The authors also highlight the value of using an expert pathologist who can rule out 'incidental pathology' (i.e. related to the background strain or environment and not the genetic modification) by a combination of comparison to control animals and prior experience.
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For 6 studies compared with this scheme, reconstructed sections generated via HistoStitcher© scored higher than reconstructions generated by an expert pathologist using Photoshop.
Lung inflammation was then blindly scored by an expert pathologist using the criteria of Johansen et al. [31] (1, normal; 2, mild focal inflammation; 3, moderate to severe focal inflammation with areas of normal tissue; 4, severe inflammation to necrosis and severe inflammation throughout the lung).
We analyzed chemoresponse as an ordinal binary variable ('optimal' versus 'suboptimal' response defined as the degree of necrosis at the time of definitive resection, assessed by an expert pathologist) using OLR.
From each case an H&E stained section that had been previously annotated for cancerous and normal areas by an expert pathologist (DMB) was used as a guide for macrodissection.
Pathology reports and diagnostic materials were obtained from the diagnosing pathology department and re-reviewed by an expert pathologist to confirm the diagnosis and to provide a consistent classification of NHL subtypes using the REAL/WHO[40] lymphoma classification.
LCM needs an expert pathologist or cytologist, limiting its extensive application.
All slides were read by an expert pathologist having no knowledge of the experimental groups.
All biopsies were read locally, and were subsequently reviewed by an expert pathologist at Johns Hopkins Medical Institutions JHMII).
All tumours were revised at the time of the study by an expert pathologist (B.B).
PCa specimens were subjected to histological examination by an expert pathologist (TVDK) for independent confirmation of the Gleason grades.
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