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The delayed effect of drug concentration can be handled using an effect compartment model (Ce,A).
The stimulatory effect of glucose on insulin secretion was included in the model using an effect compartment.
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Here, we used an effect compartment model to investigate PR and QRS prolongation previously observed in preclinical studies with the NK1 NK3 antagonist R1551.
Thus, 43% of compounds included a time delay, 89% of these used an effect compartment model.
In terms of PK/PD modeling, as anticipated, a lag time was observed between the maximum OKZ plasma concentration and the time to the maximum CRP inhibition; an effect compartment model was used to evaluate the CRP-OKZ plasma concentration relationship.
An indirect effect requires an effect compartment with rates of appearance and disappearance.
Calculations of brain distribution are often performed by modeling the brain compartment as an effect compartment (15, 45).
Equation 2 describes the rate of change of piperacillin concentrations in an effect compartment.
We model the cardiovascular system using a compartment model.
VT was estimated using a two-tissue compartment model.
PET data were analysed using a one-tissue compartment model.
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