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To have a two-tail significance test, a significance level of α = 0.05 and 90% power to detect a difference as small as 0.5, for a standard deviation of 0.72, and using an allocation of 3 2 for the prednisolone and placebo groups while allowing for a 20% dropout rate, the study required at least 66 patients to be treated with prednisolone and 44 to be treated with placebo.
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On this basis, using an allocation ratio of 2 : 1 in favour of MA, a two-sided test of 5%and90%0% power suggested that 220 patients would be required (Machin et al, 1997).
Separate block randomisation sequences will be produced for each stratum using an allocation ratio of 1 1 and a block size of 4 to ensure comparison groups are of approximate size.
Randomisation will be completed using an allocation ratio of 1 1 1 1.
Practices will be allocated in a ratio of 2 1 to the Intervention or Waitlist group, using an allocation schedule provided independent of the study team, by the Centre for Epidemiology and Biostatistics at the University of Newcastle.
To allow for potential clustering effects in the intervention arm we used an allocation ratio of 2 1 (intervention: treatment as usual).
The optimal sampling intensity of the final sample can be determined using a Neyman allocation of plots (or an optimal allocation of plots if the plots have variable costs in different strata) using the traditional approach to estimating the appropriate sample size [66].
The optimal sampling intensity of the final sample can be determined using a Neyman allocation of plots (or an optimal allocation of plots if the plots have variable costs in different strata) using the traditional approach to estimating the appropriate sample size [ 66].
At the time of the recruitment, at 12 13 weeks' gestation, a computer randomization was used with an allocation of 1 1 in each group.
While they use a random allocation of LCTs, we compare a random allocation with a clustered one using socio-demographic information, although here the focus is the load profile impact.
The first signal does not use DFT precoding and the second signal uses a random allocation of the subcarrier blocks instead of a regular one.
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