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3 5 Therapeutic approaches using alternative mechanisms of action are therefore an important unmet need for this patient population.
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Alternatively, mammalian hair cells might use alternative mechanisms of cisplatin uptake that are less sensitive to pH or perturbations in mechanotransduction.
Although phages that use alternative mechanisms of attachment (e.g. tailed phages which attach to their hosts through an appendage instead of directly with their capsid components) may be less evolutionarily constrained than G4, it is also possible that specialist phages often occupy regions of sequence space from which generalist genotypes are inaccessible.
This conclusion is supported by the fact that a mutant of TERT lacking the capability of extending telomeres still retains its tumorigenic properties in cells that use alternative mechanisms of telomere maintenance [ 21].
Rapamycin and its analogues are promising new drugs that use alternative mechanisms to inhibit the growth of breast cancer cells [ 4, 5].
In the absence of a PP pathway, M. suis must use alternative mechanisms to generate NADPH.
These results indicate that many aspects about the mechanism of TIEG proteins still remain unknown and suggest that TIEG might be using alternative mechanisms in different cellular contexts.
In the absence of classical stress response mechanisms which are crucial for the success of many foodborne pathogens, it is imperative for C. jejuni to use alternative mechanisms to survive in different environments.
The Article 29 Working Party, the body made up of representatives of individual European Member States' data protection authorities (DPAs), has said today that it will not be taking enforcement action against companies that are using alternative transfer mechanisms in the wake of last year's Safe Harbor strikedown.
The code "women left alone to find alternative coping" described participants' feelings of isolation resulting in using alternative coping mechanisms for managing their depressive and suicidal thoughts.
For intensive lifestyle interventions proven efficacious in the research setting to be successfully translated into routine clinical use, however, alternative mechanisms of delivery must be sought that are both scalable to the large, growing population of obese or overweight patients with additional risk factors and sustainable to provide ongoing patient self-management support and monitoring.
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