Sentence examples for using agents that target from inspiring English sources

Our data suggest that it may be possible to design a very effective therapy for AML using agents that target the reversal of the following three epigenetic "lock" mechanisms that silence gene expression: DNA methylation, histone methylation, and histone deacetylation.

Future clinical trials using agents that target Bcl-2 and/or Bag-1 in breast cancer should focus on hormone receptor-positive patients, and all studies should incorporate assessment of target expression in pretreatment tumors to assess the association between target expression and response to therapy.

Although the beneficial results to date have been seen mainly with drugs that bind to receptor ligands (e.g., VEGF) involved in angiogenesis, further improvement in patient outcomes may be achieved using agents that target this pathway by other mechanisms (e.g., kinase inhibition).

However, where it is most clinically useful is as a predictive marker used to guide treatment decisions about whether to use agents that target this receptor such as trastuzumab [ 3].

Their approach relied on using agents that directly target vascular endothelial growth factor (VEGF) or its receptor (VEGFR) on endothelial cells.

How this would be facilitated using agents that rely on possibly counterproductive targeting is not straightforward.

Since epigenetic changes are reversible, they are promising targets for chemotherapy using agents that inhibit DNA methylation [ 3, 4].

This property might have a clinical benefit when considering using cytotoxic agents that target specific points in the cell cycle [ 54].

The development of clinical trials using therapeutic agents that target components of the innate immune system suggests that these advances may soon culminate in new medications for treating patients with systemic lupus erythematosus.

Doxorubicin and etoposide are widely used anticancer agents that target human type IIA topoisomerases (Top2) resulting in the inhibition of DNA replication [ 39, 40].

Thus, we hypothesized inactivation of STAG2 could create a synthetic lethal combination with one or more currently used therapeutic agents that target either DNA replication or repair.