Interestingly, recent in vivo studies, using a wide dose-range, suggest that even the "mixed" (i.e. with a fixed ratio of affinities) serotonin (5-HT) and norepinephrine (NE) reuptake blockers venlafaxine and duloxetine act mostly as selective serotonin reuptake inhibitors (SSRIs) after systemic administration [2].
However, despite using a wide range of doses, we observed no significant dose response effect with unilateral PPC infusions.
At best, these extrapolated high in vitro concentrations may be labeled as the high-end limit of an in vitro study using a wide range of doses.
In vivo effects also have been reported based on studies using a wide range of doses, animal models, and end points.
Although results of some in vitro assays have suggested that BPA is a weak environmental estrogen (Vandenberg et al. 2007; Wetherill et al. 2007), important in vivo effects have been found using a wide range of doses, animal models, and study end points.
In line with our hypothesis, FitzGerald et al., using a wide range of aspirin doses, 20 2600 mg, proved that lower doses of aspirin possessed a greater inhibitory effect on thromboxane A2 than prostacyclin metabolites, while increasing doses of aspirin suppressed excretion of both thromboxane A2 and prostacyclin metabolites in healthy volunteers [ 33].
In this article, we analyze a clinically based two-dimensional (2D) quantitative dose comparison case using a wide range of new and old comparison tools.
The effective dose range (IC10 IC80) was identified using a wide range of dasatinib concentrations (0.001 10 μmol l−1).
The effective dose range for each drug (IC10 IC80) was identified using a wide range of lapatinib concentrations (0.031 10 μ M).
Excision was performed using a wide excision.
Therefore, we used a wide range of doses to ensure encompassing lowest dose for an observable effect, as well as the highest dose for maximal effect (Belz et al. 2007).
