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We addressed this hypothesis in vitro and in vivo using a well established pharmacological inhibitor of ROCK, the small molecule Y-27632.
Transgenic mice were submitted to chronic psychosocial stress using a well established experimental paradigm that serves as a model for depression[18].
Tumor formation and metastasis in vivo were examined using a well established mouse mammary tumor model.
The PT was performed by an experienced consultant or by a registrar supervised by a senior consultant in the ICU using a well established technique described elsewhere [ 3].
Furthermore, the data were collected prospectively by investigators with experience in community-based research using a well established and validated measure of HRQOL, the SF-36.
Proliferative capacity of the cancers was evaluated using a well established method and represented as the volume corrected mitotic index (VCMI) [ 18].
Similar(54)
Using a well-established mouse basaloid breast tumor model, we show that two differentiated cell types that comprise this tumor are interactive.
Using a well-established readout of cellular response, calcium signaling, allowed us to identify novel correlates between mechanical stimulation and cell responses.
In a study last month, Dr. Lin and colleagues looked at 1,984 older adults beginning in 1997-8, again using a well-established database.
For the study, which appears in the March issue of Pediatrics, the researchers recorded food intake using a well-established food frequency questionnaire and added specific questions about how often the teenagers ate breakfast.
The biocompatibility of the chip surface is investigated using a well-established cell line.
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