To explore this further, hESCs (WA07) were differentiated into motor neuron progenitor cells using a well-established protocol.
Using a well-established mouse basaloid breast tumor model, we show that two differentiated cell types that comprise this tumor are interactive.
One of the main limitation of this study is the use of a HuH7 cell line derived from a well differentiated liver carcinoma [ 35].
In the present study, the tumor compartment was modeled using a human, well-differentiated, epithelial hepatic tumor line, HepG2 [ 18], and the stromal compartment was modeled using the human hepatic stellate cell line, LX2 [ 19- 21].
To determine a possible molecular link between the autophagy process and this phenotypic regulation, we used a well-characterised cellular model, the differentiated, immortalised, nontumorigenic hepatocytic cell line MMH, capable of undergoing a reversible EMT upon TGF β stimulation.
We used a well-established early marker for neutrophil differentiation, CD11b, as our surrogate for 'differentiated' and 'undifferentiated' state [ 37].
In another morphological study [ 11], two disease progression models were used: the well differentiated and poorly differentiated models.
Three human HCC cell lines were used in this study viz Huh-BAT (a well-differentiated BA-transporter transfected HCC cell line), Huh-7 (a well-differentiated HCC cell line), and SNU-761 (a poorly differentiated HCC cell line) 23, 24, 25.
Biopsy revealed a well-differentiated adenocarcinoma.
Histopathological examination suggested a well-differentiated adenocarcinoma.
Biopsy results yielded a diagnosis of a well-differentiated adenocarcinoma.
