We provide evidence using a well characterised developmental model that dorsal cord induction of Olig2 is dependent on MAPK activity that antagonises BMP mediated signalling resulting in cytoplasmic sequestering of C-term-pSMAD1.
Taking these factors into consideration we examined the feasibility of applying this novel multi-marker approach to TSE diagnosis using a well characterised experimental murine model of TSE disease, initially using brain tissue in these studies as the major pathology in TSE disease is confined almost without exception to the CNS.
The present study has the advantage of using a well characterised population representative of the general population, with detailed phenotyping of mother offspring pairs.
A strength of our study is that it uses a well characterised population-based cohort to estimate the prevalence of features of OA at different joint sites using a sensitive imaging modality, namely ultrasound.
We used a well characterised technique to isolate chromatin-associated, nucleoplasmic and cytoplasmic RNA from HeLa cells transfected with each β-globin plasmid and the EPO control plasmid (Wuarin and Schibler, 1994).
Using a well-characterised commercial activated carbon as an example system, we modelled high pressure hydrogen sorption isotherms and identified the operating conditions for which there is a significant increase in storage capacity from using an adsorbent as opposed to storage in the same volume via compression of hydrogen at the same temperature.
Here, using a well-characterised empirical system [11] [14], we explored the replicated metapopulation dynamics of two and three species host-parasitoid assemblages, using the bruchid beetles, Callosobruchus maculatus, C. chinensis, and the parasitoid, Anisopteromalus calandrae.
Using a well-characterised cohort of prostate cancer patients, we have previously reported that expression levels of phosphorylated EGFR (pEGFR-IR) and CB1 receptor (CB1IR) in tumour tissue at diagnosis are markers of disease-specific survival, but it is not known whether the two markers interact in terms of their influence on disease severity at diagnosis and disease outcome.
Representative tissue sections from these sarcomas were analysed by immunohistochemistry using a well-characterised anti-pRB monoclonal antibody.
We propose and test a general method to deduce regulatory motifs in promoter regions of mammalian species with restricted genomic sequence by using a well-characterised reference genome.
Bailey and colleagues, using a well-characterised antibody, could not detect α-lactalbumin in human breast cancers [ 9], whilst it was present in pregnant breast and in lactational foci seen in normal virgin women taking oral contraceptives.
