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We validated the LCQ-acute for acute cough using a well accepted QOL instrument development methodology [ 9].
An alternative strategy to set up the "ground truth" is using a well accepted reference data set generated by a reliable independent technology, such as real-time PCR for gene expression measurements.
2 The authors use a Markov decision analytical model to discount future events, to extrapolate from the two year RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial, 4 and they compare various health states using a well accepted metric, quality adjusted life year (QALY).
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In order to detect actin in both stages of Giardia, we first analyzed its distribution using TRITC-phalloidin –a well accepted specific tool for structured actin identification–.
All of the theoretical analyses are confirmed using a well-accepted numerical model.
In the current study, we established the reliability of the method using a well-accepted standard of truth dataset of homologous proteins, and demonstrated that the method has a wide dynamic range, that goes down to as low as 0.01% of homologs.
The same issue of comparing a majority using a well-accepted tool with a minority of non-users would also apply in this situation.
First of all, unlike the simulated case, the true tree is not known with complete confidence, and accuracy of reconstruction can only be determined by using a well-accepted reference tree that may contain some errors.
ISRs over each sampling period were derived by using a well-accepted two-compartment model described by Van Cauter et al. (12) of C-peptide distribution and degradation and standard parameters for C-peptide clearance estimated for each subject, taking into account body surface area, sex, and age.
These responses are well described in peripheral tissues, using the (reversed) Arthus reaction, a well accepted experimental model of antibody-mediated inflammation [ 10].
The data of HRV, a well accepted and widely used indicator of autonomic function [36], also indicate a reduction in autonomic functions as evidenced by the reduction of time domain calculations (SDNN, RMSSD, NN50, pNN50%) at successive days after infection.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com