Concentrations of saracatinib in human plasma were determined using a validated solid-phase extraction followed by HPLC-MS/MS at PRA International.
Belinostat plasma concentrations were determined at Covance using a validated method involving solid-phase extraction, separation with acetic acid acetonitril gradient on reversed phase C18 silica and MS/MS using penta-deuterated belinostat as the internal standard.
Plasma samples were analysed for FF (150 μl of plasma) by solid phase extraction using a validated analytical method based on solid phase extraction (with [C H3]-GW685698 as the internal standard) followed by high performance liquid chromatography with tandem mass spectrometry using an Applied Biosystems API-5000 (Applied Biosystems/MDS Sciex,Foster City, USA).
The quantification of nucleotides was performed using a validated technique with on-line solid-phase extraction coupled with liquid chromatography triple quadrupole tandem mass spectrometry (LC MS/MS).
The pressures exerted on the walls of rectangular planform steel flexible-walled silos by several different stored granular bulk solids are investigated using a validated finite element model that has been used in several previous studies.
The analysis of testosterone and DHT concentrations in serum were assayed using a validated GC assay with MS detection after solid-phase extraction, derivatization and liquid liquid extraction with n-hexane.
Imatinib concentration was measured using a validated method by high-performance liquid chromatography after solid phase extraction (Widmer et al, 2004).
The procedure takes advantage of using a validated thermodynamic model to enhance the accuracy of fraction solid evaluations, since the enthalpy of the phases vary according to their solute mass concentrations and temperature.
TU and DHTU concentrations were determined using a validated liquid chromatographic (LC) assay with mass spectrometry (MS) detection after solid-phase extraction.
Plasma and lung caspofungin concentrations were determined by using a validated high-performance liquid chromatography method with fluorescence detection [ 20] after a solid-phase extraction (Bond Elut™ column; Agilent Technologies, Santa Clara, CA, USA).
Plasma samples were analysed using a validated analytical method.
