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Experimental parameters were optimized using a univariate experimental design.
Experimental parameters were optimized using a univariate experimental design, and the matrix effect of seawater was preliminarily investigated.
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The extraction and hydrolysis conditions were optimized using an univariate and experimental design, respectively, and the quantification of pfaffic acid by high performance liquid chromatography with diode-array detection (HPLC-DAD) was validated.
The statistical significance of the main chemical and instrumental conditions was studied using a two-level Plackett Burman experimental design approach and the significant variables were further selected using a univariate approach.
To fulfil this objective, three important dHS-SPME experimental parameters that influence extraction efficiency (fibre coating, extraction time and temperature of sampling) were optimised using a univariate optimisation design.
Using a univariate approach these parameters were optimized.
First, the PLE conditions were optimized using a univariate approach.
We propose the Intersection method that is simple to implement, using a univariate hotspot detection method.
In addition, the prognostic value of GNA13 expression for OS and DFS was analyzed using a univariate analysis model on these clinialpathological parameters (Tables 2 and 3).
This is usually made using a univariate approach, which demands a large number of experiments, being time and money consuming.
GWAS have successfully identified many novel genetic loci associated with complex traits using a univariate regression-based approach.
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