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Collectively, using a unique model of inducible and reversible loss of adipocytes, our observations suggest that adipocytes are required for proper development during puberty and for the maintenance of the ductal architecture in the adult mammary gland.
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However, the HRH Program uses a unique model with the USF working on a country-developed agenda under the leadership of Rwandans.
In this study we have used a unique model and large-scale gene expression profiling to study the transcriptional regulation of biological processes occurring during the differentiation of multipotent stem cells.
Our results strengthen the generality of the BR genes as a model system and provide essential background for in-depth studies of mRNP biogenesis and functions using a unique eukaryotic model system.
This study was designed, using a unique cell model system, to gain insight into the molecular events of anticancer agent-induced cardiomyocyte injury.
To this end, this study was designed to examine the role of Akt2 in acute paraquat exposure-induced cardiac contractile and mitochondrial injury using a unique murine model of Akt2 knockout.
Using a unique mouse model we show that B cells induce negative selection of self-reactive thymocytes in a process that leads to the deletion of these cells whereas regulatory T cells are spared.
Using a unique culture model of luminal breast epithelial cells (BPEC-T), Godar and coworkers demonstrate that p53 binds to the promoter of CD44 [ 2], a commonly used marker of cancer stem cells [ 3], and represses CD44 expression.
In this study, we have analysed the dynamics of chromosomal instability and chemosensitivity during glioblastoma progression using a unique cell model comprising three cell lines derived from surgery specimens of a long-term surviving glioblastoma patient.
Using a unique mouse model containing a disabled palmitoylation site within ERα that is essential for MISS, we recently demonstrated that MISS is essential for the endothelial effects of E2, including its acceleration of endothelial healing.
In an attempt to address the regulation of the adipocyte/osteoblast balance at the level of gene transcription in a comprehensive and unbiased manner, we performed a large-scale gene expression profiling study using a unique cellular model, human multipotent adipose tissue-derived stem cells (hMADS).
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