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Psychophysical evidence using a trial based Go/No Go paradigm showed that rats used intensity cues while being unable to use frequency and instantaneous kinematic cues offered to them (Gerdjikov et al. 2010).
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It has been found that moving the simulator like a real motorcycle to the greatest possible extent does not give the best riding feeling, so gains and other adjustable parameters of the washout filter have been tuned using a trial-and-error procedure based on the subjective evaluation of feelings.
A probabilistic sensitivity analysis indicated that the likelihood that the DESMOND programme is cost effective at a threshold of £20 000 per QALY is 66% using trial based intervention costs and 70% using "real world" costs.
The estimated incremental cost per QALY gained is £5387 using trial based intervention costs and £2092 using real world costs.
Therefore, the total lifetime cost of patients receiving the DESMOND intervention is £16 289 using trial based intervention costs and £16 162 using real world costs, £209 (95% confidence interval −£704 to £1137) and £82 (−£831 to £1010) more expensive than usual care, respectively.
The approach of using trial based data as the basis for modelled costs is common-place, allowing for provision of real data for the models [21], [22].
In Experiment 5, contrast was updated on each trial using a procedure based on the QUEST algorithm.
This procedure has been used in an ongoing trial based at McMaster University and data collection will follow the same standardized format.
When restricted to the seven trials using a patient based assessment of interpersonal care skills (the inclusion criteria for the present review) only two of the seven studies in the Cochrane review showed a positive significant effect, a result not substantively different from the results reported here [ 35, 46].
Randomisation occurred through the Nottingham Clinical Trials Unit using a web based database and randomisation system.
Here we focus on the first question, and consider the use of trial based economic evaluations to obtain precise estimates of incremental cost effectiveness.
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