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This suggests an ergogenic effect was apparent, in agreement with other studies using a time to peak alkalosis NaHCO3 ingestion strategy [10, 28].
Using a time to peak HCO3 - strategy seems to cause no dose-dependent effects on performance for exercise of this duration and intensity; therefore, athletes may consider smaller doses of NaHCO3 to mitigate gastrointestinal (GI) discomfort.
The primary endpoint will be analysed using a time to event approach.
We assessed tolerance using a time to death (TTD) assay, a common measure of relative tolerance among different experimental groups (Bridges and Semlitsch 2000; Cothran et al. 2013).
It is important to note that the effect on the results of economic modelling when using a time to death approach (rather than progression-based approach) for HRQL in a model may be dependent upon the length of time patients live in a post-progression state.
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The aim of this study was to investigate the use of three treatment-effect measures in the analysis of randomized trials using a time-to-event endpoint and assess their influence on the results.
Data from sites in the same cell of the transmission matrix were analysed together and five continuous probability distributions (gamma, Weibull, log-normal, log-logistic, exponential) were fitted to the data using a time-to-event likelihood for severe events, or Poisson likelihood to account for the person-time at risk for the incidence of clinical malaria.
Using a time-to-infection study design to examine the relation between growth inhibition in vitro and protection against blood stage infection, weekly finger stick blood samples were examined by microscopy for malaria parasites for the 11 weeks following administration of anti-malarial drugs.
The pharmacodynamic data were modeled using a time-to-event model linked to the pharmacokinetic model.
All of the outcomes were measured using a time-to-event survival analysis approach.
57 Results will also be assessed using a time-to-event regression model.
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