After calculating Pearson's correlation coefficient (PCC) for each TF→miRNA associations using a time-lagged expression correlation analysis and the interpolated expression data for TFs and mature miRNAs, we finally derived a set of 1,989 TF→miRNA associations (see Additional Files 3) for 37 miRNAs and 258 TFs (see Additional Files 4), each associated with a PCC value (see Methods).
With the help of time-course expression data for miRNAs and TFs during monocytic differentiation we evaluated each predicted association using a time-lagged expression correlation analysis.
Subsequently, we scored each predicted TF→miRNA association using a time-lagged expression correlation analysis to get a measure of reliability for the predicted associations.
To do so, we assessed synchrony separately from variations in the firing rate of individual neurons by using a time-resolved cross-correlation method (Pauluis and Baker 2000; Baker et al. 2001) because changes in correlated activity may be confounded by simultaneous variations in average firing rate.
The two-condition-based GWAS was followed by integration with network-derived metabolite transcript correlations using a time-course stress experiment.
In order to identify the key regulatory genes involved in the control of lipid metabolism, Gargouri et al. [ 79] used a time-lagged correlation analysis to identify putative TRs of cellular metabolism, before and after the onset of lipid accumulation.
Methyl group order parameters were determined as described, 19 using a rotational correlation time of 86 ns, as derived from the program HYDRONMR.
N T1, T2 and heteronuclear NOE NMR data for CobR (Supplementary Figure S3 at http://www.bioscirep.org/bsr/034/bsr034e120add.htm) were analysed using ModelFree 4.0 with results shown in Figure 2 using a global correlation time τm of 9.44±0.93 ns that was estimated from the average T1/ T2 ratio over the structured regions.
Therefore, we developed a high resolution modality consistent with the binding dynamics observed within adhesions using time correlation of TIRF image time series.
Using a rotational diffusion correlation time of 7.3 ns, the fitted relaxation dispersions yield Nβ Sβ values of 4.5 ± 0.1 and 4.3 ± 0.1 for the lactose-bound and apo states, respectively.
