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The proportional hazards assumption was investigated graphically, using a test based on the Schoenfeld residuals.
The proportional hazards assumption was investigated graphically, using a test based on the Schoenfeld residuals [23] and time-dependent Cox models [24] using interactions between the vaccine effect and one-degree fractional polynomials of the time.
Non-linear differences were assessed using a test based in the third-order moment [ 28].
The proportionality assumption was investigated using a test based on the Schoenfeld residuals (Grambsch and Therneau, 1994).
We checked the proportional hazards assumption for this model by using a test based on the weighted residuals and found no evidence of deviation from this assumption.
Differential expression of genes was evaluated using a test based on the negative binomial distribution as integrated in the Bioconductor R package DESeq [ 48], with a standard level of p ≤ 0.05 indicating significance.
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One reason for this low power is that the standard GWAS uses a test based on an additive model.
We evaluated the system using a test base of more than 2000 cases.
We first tested the ASTI critiquing module using a test base involving 59 clinical cases and 652 test cases for hypertension, 56 and 877 for type 2 diabetes, 31 and 348 for tobacco addiction, 31 and 256 for dyslipaemia, 8 and 123 for atrial fibrillation and 17 and 136 for thrombo-embolic risk (totals: 202 and 2392).
These associations can be found using a test statistics based on all n samples.
An experimental demonstration, using a test case based on the design and manufacture of an aerospace part, has been realised.
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