Stothard et al. acknowledged using a stringent criterion for normality: "Children were regarded as having a good outcome only if they were essentially indistinguishable from controls" (p. 413).
Using a stringent criterion of 0 mismatches within the 16 nucleotide tag alignments, most of the tags aligned to the models but large numbers of tags did not.
Using a stringent criterion to ascertain ANVUGIB events from Medicare claims, the occurrence rate of ANVUGIB among patients on dialysis was estimated at 57 episodes per 1000 person-years [ 1], almost two orders of magnitude higher than in the general population.
It is possible there are more PSFs that can be identified, but given we do not have a large subject sample size, we use a stringent criterion of p<1E-4.
We used a stringent criterion to identify a total of 2886 high-confidence copy number variable regions (CNVRs), which span 10.28 Mb (or 2.69%) of the rice genome, overlapping 1321 genes.
To select genes that are most strongly associated with the prototypes, we use a stringent criterion of | z| ≥ 16, which is well above | z| ≈ 5 that corresponds to a Bonferroni-corrected P value of 0.05.
We used a stringent criterion (each site with at least three ESTs/reads support) and new annotation file (v4.3) to filter the unique poly(A) site and obtain PACs that can appropriately define high-quality APA events.
In fact, after controlling for multiple testing and using a stringent significance criterion (FDR < 0.01), we were able to identify a set of 3,078 trustworthy miRNA-target relations involving 117 (39%) of 309 selected miRNAs.
Using a stringent statistical criterion (E-value of a chip-wise normal fit), transition values are converted into three possible discrete classes: up-regulated (u), down-regulated (d) or stable (s), respectively.
Using a stringent selection criterion (a Guang-lu-ai 4 to Nipponbare signal ratio of 1 : 2), we identified 500 protein-coding genes that were contracted in Guang-lu-ai 4, and only 19 genes that were duplicated (signal ratio > 2.0) (Additional file 4, Table S3).
