Sentence examples for using a stricter threshold from inspiring English sources
Because of the jitter or variability in localization errors, using a stricter threshold might lead to erroneous exclusion of some trials in which participants reported the location of another object but in a relatively imprecise manner.
Only half were reproduced successfully using a strict threshold for significance that was set at P < 0.0001 (the P value is a common test for judging the strength of scientific evidence).
Using a strict threshold of q < 10-10, we identified 22,554 overlapping binding sites.
DOI: http://dx.doi.org/10.7554/eLife.08274.004 10.7554/eLiFigure74.005 Figure 1 figure supplement 2. c-Fos+ cell density in the IL calculated in the analysis using a normal threshold and in an additional analysis using a strict threshold.
Using a strict threshold of significance, there are 51 EST showing a difference in expression by behavioral type (d.f. 1,>36; log P < −5); 23 of these show a greater than twofold difference (Fig. 3).
Using a strict threshold of 95% CI resulted in acceptable false positive rates for all statistics, whereas a liberal threshold of 90% CI resulted in reduced specificity (in particular for the base-to-peak and peak-to-peak P300 statistics), without much increase in sensitivity.
Therefore, we chose to use a strict threshold to detect and subsequently analyze only high-confidence p53 peaks.
The 188 genes used in the survival signature were selected by using a stricter P-value threshold, 0.01.
This reduction in the sensitivity and precision of imbalance detection is similar to the reduction seen when using a stricter binomial p-value threshold and is likely related to the increased p-values of false positive sites reported above.
These analyses were exploratory in nature, and were to maximize sensitivity and to avoid missing significant findings with the use of a stricter threshold.
Given the large number of tests for association performed and the subtle effects of naturally occurring variants on olfactory behavior, none of the polymorphisms were significant using a strict Bonferroni-corrected significance threshold.
