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Exact(7)
For the UK MSM clade we estimated an origin in 1992 (1988 1997) using a relaxed clock model, and 1990 1985 to 19944) using a strict clock model.
Although the 95% HPD values for the skyline plots under the relaxed clock were too wide for meaningful interpretation, those generated using a strict clock gave a reasonable demographic signal (Figure 2 and S2).
We analysed 50 replicates with Physher and BEAST using a strict clock.
In contrast, the intervals remained similarly narrow for all levels of rate variation when analysed using a strict clock in MCMCTREE.
This is the case in all *BEAST analyses with a relaxed clock model, whereas all *BEAST analyses using a strict clock model recover clade B, although with rather low support (PP mean 0.80 ± 0.06; not shown).
We therefore proceeded using a strict clock model as the simplest possible scenario and checked afterwards that the estimated substitution rates were in line with previous findings for HCV.
Similar(53)
All EBSP analyses used a strict clock.
We used a strict clock with a random starting tree.
The estimate of the standard deviation of the lognormal distribution of rates did not overlap 0, so we could not use a strict clock with these data.
We used a strict clock model (which we preferred because we have a single secondary constraint), a Yule process tree prior, and MCMC chains of 10 million generation length, with parameters sampled every 1000th generation.
We therefore used a strict clock model, and calibrated it with a hummingbird stem group fossil from the oil shale of Messel in Southern Germany that provides a minimum age for the divergence between hummingbirds and swifts [ 36].
More suggestions(15)
using a strict cutoff
using a strict biopsy
using a strict randomization
using a strict protocol
using a strict grading
using a strict criterion
using a strict license
using a strict interview
using a strict threshold
using a strict analysis
using a strict approach
using a strict mapping
using a strict quota
using a strict peak
using a strict sedation
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