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Using a strict approach of PI-RADS v.2 guidelines, this should be grading as 4/5 on T2 and 4/5 on DWI, with a low ADC.
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We achieve this by analyzing divergence times of sequences using a strict phylogenetic approach, as opposed to divergence times of species using a phylogenetic-coalescent approach [ 19].
The pattern of acquisition of new domains at the N-terminus of HECT proteins across the eukaryote tree of life was inferred using a strict parsimony approach based on phylogenetic information from BI and ML trees.
A reciprocal best-hit approach was used to determine highly similar 1 1 orthologs using a strict e-value cut off of 1 × 10−10.
A suggested approach for using the new algorithms in practical QTL analysis is to exploit the two-phase DIRECTDIRECT algorithm, using a strict stopping criterion, for determining x opt and RSS opt for the genetic data.
All included systems incorporated some form a hierarchical approach with three systems (Wigglesworth, Aberdeen and ReCoDe) using a more strict approach than the others.
Further, the low risk of cannabis use suggests government should use "a strict legal regulatory approach rather than the current prohibition approach" to manage the substance, the researchers write.
Thus, the approach to case selection described in this paper may be tightened using a stricter case selection criterion if the objectives of the study require greater specificity.
"I would be disappointed if people used a strict clinical trial approach," Dr. Freed said.
It is also possible to use a less strict approach for comparison of multicomponent InChI identifiers.
However, a strict approach was used which precluded the participation of informal sellers such as those in markets and consequently resulting little to change their practices [ 37].
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