Norepinephrine was used in a stepwise manner to achieve predefined endpoints: mean arterial pressure (MAP) ≥65 mmHg and urine output ≥0.5 mL/kg/h.
Intravenous volume expansion and intravenous norepinephrine were used in a stepwise manner to achieve predefined endpoints of resuscitation from invasive hemodynamic monitoring: mean arterial pressure (MAP) >65 mmHg, central venous pressure (CVP) between 8 and 12 mmHg, urinary output >0.5 ml/kg/h.
Thus, short- and long-acting bronchodilators, acting via β adrenoceptors (β2 agonists) and anticholinergic pathways, are recommended to be used in a stepwise manner, with the addition of inhaled steroids later in the disease.
Interaction and association/correlation analyses using linear and logistic regression with permutation were performed using PLINK Software Package Version 1.04, in a stepwise manner to maximise our ability to detect associations and to minimise multiple testing.
The reactive oligomers could be cured in a stepwise manner using successive high temperature treatment steps.
The 14 candidate markers for EOC described above were evaluated in a stepwise manner using three overlapping serum sets of increasing complexity: the Filtering set, Mini-Triage set, and Triage set (Table 1).
ADRs were independently identified by expert reviewers in a stepwise manner using the Howard criteria.
Powell's energy minimization of the complex was achieved by a stepwise manner using AMBER 7 FF99 parameters.
[ 13] They recommend treatment of allergic rhinitis in a stepwise manner (using a combination of allergen avoidance, pharmacotherapy and immunotherapy) based on the duration and severity of disease, rather than on the type of exposure (i.e. seasonal, perennial, occupational) as in previous guidelines.
The sequences corresponding to the catalytic domain (as defined by Hanks [ 47]; 285 amino acid residues corresponding to exon 3 to exon 10 in Arabidopsis; see Figure 1) and part of the 3' region (corresponding to 78 amino acid residues; exons 11 and 12 in Arabidopsis) were aligned manually in a stepwise manner using Se-Al; other regions were too variable to align.
