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The protection studies were carried out by using a standardized mouse model of botulism [26].
In this context, we further evaluated all three inhibitors using a standardized mouse model of botulism [26] to determine if they can protect mice against either extracellular or intracellular BoNTA during the period of 8 half-lives of the test inhibitor in a single-dose experiment.
Inasmuch as the MLST data showed that more than half of the strains from North America analyzed were ST28 and the second most represented ST was ST25, we performed a comparison of the virulence of representative ST25 and ST28 strains by using a standardized mouse infection model (18 ).
Similar(57)
The SSS assesses the individual reaction of mice using a standardized protocol including the evaluated of urination, defecation/diarrhea, fur condition/grooming, reduction of activity/huddling behavior and reduction of muscle tone.
CT26.WT murine colon carcinoma cells were injected intraportally in Balb/c mice after median laparotomy using a standardized injection technique.
The input dataset of mouse brain images were contributed by the Allen Institute for Brain Science and other research organizations using a standardized protocol.
We treated wild-type and IL-6−/− mice with increasing doses of PM and measured the severity of the resulting lung injury using a standardized scoring system [25].
Clinical and demographic data were assessed using a standardized protocol.
The two reviewers extracted data independently using a standardized form.
Data were extracted by two reviewers using a standardized form.
using a standardized form.
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