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Two key recommendations include: (1) parallel analyses of existing data sets using a standardized methodological approach to disentangle true differences in associations from methodological differences among studies; and (2) identification of animal studies to inform important mechanistic research gaps.
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Structured data abstraction was performed and methodological quality was assessed using a standardized checklist.
Indeed, the IMCI strategy's use of direct clinical observation of IMCI trainees' clinical practice, as conducted by a silent observer using a standardized clinical checklist, was one of our primary methodological inspirations.
All the included trials were assessed for methodological quality and outcomes of interest using a standardized form [ 12].
There were no strong or moderate studies; consequently all 24 weak articles were assessed for methodological quality and underwent data extraction using a standardized form.
We decided to develop potential QMs using a standardized, rigorous, approved, evidence-based approach following previously defined recommendations to ensure high methodological quality and maximal clearness of our outcomes [ 13, 14, 55].
Two independent reviewers selected the studies, extracted data using a standardized form, and assessed the risk of bias using the Newcastle-Ottawa scale and a checklist of key methodological elements (for example, use of massive transfusion protocol, survival bias).
The data on the methodological quality (allocation concealment, intention to treat analysis and Jadad score) of the trials were collected using a standardized data extraction form.
The data was collected using a standardized questionnaire.
Symptoms were obtained using a standardized in-person interview.
MAIN OUTCOME MEASURE: Patient satisfaction using a standardized PSQ.
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