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Serum samples were collected using a standardised sample collection protocol and stored at −80 °C until use.
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Further prospective controlled studies with large sample size using a standardised clinical protocol and longer follow-up, are needed.
All breath samples were collected using a standardised technique during a pressure and flow-controlled exhalation into a polyethylene reservoir as previously described [ 19].
To ensure preservation of the CNS molecular cytoarchitecture, samples were processed using a standardised procedure and rapidly frozen to −70°C after removal at autopsy [ 21].
Two independent reviewers extracted means (final scores or change score), standard deviations, and sample sizes from studies using a standardised data extraction form.
These samples had been taken using a standardised method [ 5].
extracted rate information, study features and sample characteristics from the validity studies using a standardised coding sheet.
Each author extracted relevant information independently using a standardised data extraction form, pre-tested on a subset of the sample.
A disadvantage to using a standardised interview schedule is that it is resource intensive, limiting the sample size achievable.
12 The balance of the covariates before and after matching was assessed using a standardised difference since, unlike significance testing, it is not confounded by sample size.
Samples were centrifuged and plasma was stabilised using a standardised volume of metaphosphoric acid and measured using a fluorometric assay.
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