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These questions are scored by using a standardised grading system.
Although the toxicity data was recorded using a standardised grading system, there is a subjective element to assessing non-haematological toxicity and we could not control for variation between individual investigators.
The thickness range of the tear film lipid layer was deduced from interference patterns observed using a standardised grading scale, where Grade 1=13 50 nm; Grade 2=30 50 nm; Grade 3=50 70 nm; Grade 4=80 90 nm; Grade 5=90 180 nm; Grade 6≥200 nm.
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independently recorded data using a standardised form.
Demographic and clinical information were collected using a standardised form.
Sociodemographic information was collected using a standardised form.
COVIS data are collected using a standardised form [ 3].
This will be documented using a standardised form.
The primary study data were extracted using a standardised form.
Data was extracted by one reviewer and checked by a second reviewer using a standardised form.
We used a standardised form completed by two reviewers independently.
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