Previous results using a standard trial-based Go/NoGo psychophysical task without background stimulation and similar stimuli, predicted that the animals should have difficulties to discriminate these stimuli, as intensity was found to be the decisive cue in the earlier task (Gerdjikov et al. 2010).
We will test for statistical heterogeneity between trial results using a standard χ test with a significance level of p<0.1, and I test will be used for quantifying inconsistency among the included studies.
A set of 10,000 corresponding target variable values were then generated by adding random normal deviates to these auxiliary values using a standard deviation chosen by trial and error to give a particular level of correlation between the target and auxiliary variables.
Heterogeneity across trials was assessed using a standard chi-squared test, with significance being set at P <0.10.
The sampling rates, detection and filtering levels were determined from a field trial using a standard commercial passive seismic system.
A study nurse-counselor verified each participant's identity and age, reviewed the informed consent document with participants, and then assessed their understanding of the trial using a standard assessment of understanding questionnaire.
This study was a single institution, unblinded dose-finding trial using a standard 3+3 design.
Two review authors (CR and VR), working independently, will extract data and summarise details of trials using a standard data extraction sheet.
For a trial completed using a standard design, the clinician will often ask: what would the CRM or some other design with memory have performed had it been employed.
The trial was performed using a standard 3+3 dose-escalation phase I design with cohorts of 3 6 patients.
The trial used a standard 3 + 3 dose escalation design as previously described, with only the HCQ dose subject to dose-escalation rules.
