Sentence examples for using a split G-quadruplex from inspiring English sources

Here, we constructed a method for specific nucleic acid detection using a split G-quadruplex (Gq) structure that can recognize target nucleic acids without competitive reactions in a bimolecular reaction and directly produce a detectable signal based on peroxidase activity.

In the presence of Hg2+, the two separated ssDNA prefer to form a metal-dsDNA complex, which results in the two G-rich segments connecting to each other and forming a split G-quadruplex complex.

The use of split G-quadruplex DNAzyme can increase the specificity of the sensor for Hg2+, and thus, increase the selectivity of the sensor.

In the presence of Hg2+, however, the stabilization of the T-T mismatch by Hg2+ can promote the folding of the Hg2+ -sensing sequence into an intramolecular duplex, accompanied by the destruction of the intermolecular duplex and the formation of an intramolecular split G-quadruplex, which can form catalytically active G-quadruplex DNAzyme upon hemin binding.

By linked bridge hybridizing-induced split G-quadruplex (SQ), we demonstrate here the construction of a simple and sensitive DNA machine for the detection of UDG activity.

In this work, to improve the selectivity of G-quadruplex DNAzyme-based Hg2+ sensors, split G-quadruplex DNAzyme was introduced in the design of Hg2+ sensor.

Therefore, in this study, we designed three pairs of split G-quadruplex probes and investigated the sensitivity and selectivity of these systems in terms of potassium ion concentration and split modes of G-quadruplex.

The satisfactory split G-quadruplex sequences (SQS) were successfully selected to be the ingredients of SQ formation.

Notwithstanding, several key issues for template-directed reassembly of G-quadruplex have not been resolved: what is the key factor for determining the sensitivity and selectivity of split G-quadruplex probes toward target DNA.

Nitroveratryl protecting groups and their derivatives have been successfully used to cage a G-quadruplex ligand telomerase inhibitor and DNA binders.

We hypothesized the involvement of non-canonical sequences that can result in local non-B DNA structures and tested this using the G-quadruplex DNA as a model.