Theoretically, a large tumor burden could be effectively eradicated using a small dose of an oncolytic virus.
We subsequently used a smaller dose of 75 ng per side (Note: this is half the dose used in the bilateral PPC experiment described below).
A complete table of all significant genes can be found as Additional File 2. The observation that most of the expression changes are upregulated is contradictory to a previous microarray study in A549 cells [ 22] which used a smaller dose of crocidolite (2 μg/cm).
The little guys release all their venom in a single bite, while adult snakes use a small dose initially, having learned it's best to save lethal attacks for the end of a fight.
The Guardian reported some users compulsively redose, consuming their whole supply when they only meant to use a small dose, and there have been other similar reports of users craving mephedrone, suggesting it may be addictive.
Although we used a small dose, meglumine amidotrizoate is also known to have a laxative effect that may also have added to the superior cleansing.
This did not occur after nebulised administration of the DNase, which suggests that if direct tracheal administration is used, a small dose should be tried initially.
TKIs are well tolerated in human leukaemia patients and could be used with a smaller dose over a longer period of time to prevent progression from mild cognitive impairment (MCI) to AD. IL performed prepared lentivirus, IHC and Morris Water Maze, MLH performed ELISA, parkin activity assays and Western blots, NMD and AF performed WB.
A target attack rate of 60%75%% was selected based on historical typhoid challenge data from Maryland, providing a balance between using a smaller and therefore more physiological exposure dose while achieving a moderately high attack rate.
The Penthrox inhaler, an improved version of the Analgizer, permits the use of a smaller dose to achieve adequate analgesia (3 6 mL vs 15 mL).
