Recent genomewide studies of invertebrate DNA methylation have used a single tissue or whole adult bodies [ 13, 14, 17, 21, 22].
Only few studies [26],[27] have performed quantitative analysis of [11C]HED data using a single-tissue compartment model, but no systematic assessment of the best tracer kinetic model was performed.
Blood sampler data were corrected for delay and dispersion by fitting the early part of the sampler curve to the ascending aorta (AA) time-activity curve (TAC) using a single-tissue compartment model with additional parameters for delay and dispersion constants [32].
Using a single-tissue compartment model covering the first 10 min of data yielded acceptable global test-retest variability (9%) for the outcome measure K 1. Test-retest variability of binding potential derived from the constrained two-tissue compartment model was less robust, but still acceptable (22%).
Kinetics of [O]H2O can best be described using a single-tissue compartment model with parameters for MBF and, to correct for partial volume and spillover effects, perfusable tissue fraction (PTF) [ 8, 9], and left ventricular (LV) and right ventricular (RV) blood volume fractions [ 10].
Thereafter, we initiated PET studies with arterial sampling in humans and used a single-tissue compartment model to estimate brain regional binding potentials [10].
Method AC3 represents a scenario of using a single "soft tissue" LAC value as would be assigned by the MRAC segmentation algorithm on clinical scanning.
The present manuscript provides an overview of organ generation using a single adult tissue stem cell, a blastocyst complementation system coupled with a specific stem cell niche, a method of decellularization and recellularization of bio-scaffold, and a combinatorial approach of tissue engineering and stem cells.
However, our platform is almost compatible to conventional IHC using a single thin-sectioned tissue slide.
